- N332B/15 (See other available formats)
- Other Names
- Actin Like 6B, 53 KDa BRG1-Associated Factor B, Actin-Related Protein Baf53b, BRG1-Associated Factor 53B, ArpNalpha, ACTL6, Actin-Like Protein 6B, Actin-Like 6, HArpN Alpha
- Mouse IgG1, κ
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- Product Citations
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ACTL6/BAF53 proteins share similar homologies to actin-related proteins and are found within the SWI/SNF chromatin remodeling complexes. ACTL6b/BAF53b protein is part of the neural specific SWI/SNF complex, which play important roles in remodeling mononucleosomes in an ATP-dependent fashion, postmitotic neural development, dendritic growth, memory, and synaptic plasticity.Product Details
- Human, Mouse, Rat
- Antibody Type
- Host Species
- Fusion protein corresponding to amino acids 39-114 of human BAF53b
- This antibody is provided in 50% glycerol in aqueous buffered solutions with preservatives.
- The antibody was purified by affinity chromatography and conjugated with HRP under optimal conditions.
- 0.5 mg/ml
- Storage & Handling
- Upon receipt, the antibody solution should be stored undiluted at -20°C, and protected from prolonged exposure to light.
WB - Quality tested
IHC-P - Validated
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 1.0 - 5.0 µg per ml. For immunohistochemical staining on formalin-fixed paraffin-embedded tissue sections, a concentration range of 5.0 - 10 µg/ml is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
- Additional Product Notes
For IHC-P application, permeabilization with 0.25 % Triton X-100 is recommended.
AB_2814576 (BioLegend Cat. No. 857403)
AB_2814577 (BioLegend Cat. No. 857404)
- BAF53b is a 426 amino acid protein with a molecular mass of ~47 kD.
Tissue Distribution: Moderately expressed in the brain and testis.
Cellular Distribution: Nucleus and cytosol.
- BAF53b is involved in the transcriptional activation / repression of select genes by remodeling mononucleosomes. BAF53b is also a component of the SWI/SNF chromatin remodeling complexes that drive enzymatic activites and chromatin structure alterations by changing the DNA-histone contacts within the nucleosome.
- BAF53 has been shown to interact with c-Myc.
- Biology Area
- Cell Biology, Neuroscience, Synaptic Biology, Transcription Factors
- Antigen References
- Yoo M, et al. 2017. Journal of Neuroscience. 37(13):3686-3697.
- Vogel-Ciernia A, et al. 2013. Nat Neurosci. 16(5): 552–561.
- Zhan X, et al. 2015. Genesis. 53(7):440-8.
- Jeonghyeon Park, et al. 2002. Mol Cell Biol. 22(5): 1307–1316.
- Gene ID
- 51412 View all products for this Gene ID
- View information about BAF53b on UniProt.org
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